Traditional neonatal guidelines estimate normal mean arterial pressure (MAP) as approximately equal to gestational age in weeks, but this rule is based primarily on data from the first 24–72 hours of life. This retrospective study evaluates whether this relationship holds beyond the immediate postnatal period by analyzing vital signs from premature infants admitted to the DHMC NICU between 2018–2025. Cohorts will be stratified by gestational age, with daily averages of MAP, heart rate, and respiratory rate aggregated across days of life. Thresholds that triggered medical intervention will also be compared to published guidelines. Background literature underscores a lack of robust, longitudinal physiologic data, despite known associations between hypotension, morbidity, and mortality. This study aims to generate a comprehensive dataset describing normative neonatal vital signs beyond early transition, guiding evidence-based hemodynamic monitoring and intervention thresholds.