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Abstracts & Posters

Vol. 1 No. S1 (2025): Special Issue: 2025 Geisel Research Poster Night

Anatomical and Feasibility Pilot Study of Selective Trans-nasal Injection of the Tensor Tympani Muscle

Submitted
14 December 2025
Published
27-12-2025

Abstract

Myoclonus of the tensor tympani muscle can produce tinnitus, vertigo, and aural fullness, yet treatments remain limited due to difficulty accessing the muscle directly. This feasibility study evaluated whether a transnasal approach through the cartilaginous eustachian tube could allow direct injection into the tensor tympani. Cadaveric trials tested injection volumes using iohexol dye to determine optimal radiographic visualization, followed by endoscopic navigation of a flexible cystoscope outfitted with microtubing and a 26.5-gauge needle. CT imaging demonstrated that a 100 μL injection yielded adequate visibility with minimal diffusion, and transnasal needle placement at the isthmus was feasible. Endoscopic images confirmed successful penetration of the eustachian tube sidewall during injection. This proof-of-concept supports the anatomical plausibility of targeted delivery to the tensor tympani using minimally invasive transnasal techniques. Future steps include confirming whether injected material reliably reaches the muscle belly, repeating procedures across additional cadaver heads, and expanding toward eventual clinical application.

References

  1. References are available on the poster PDF.