Continuous non-invasive blood pressure (CNIBP) monitoring seeks to bridge the gap between intermittent oscillometric cuff measurements and invasive arterial lines, providing beat-to-beat hemodynamic data without the risks of cannulation. This review synthesizes clinical validation data for commercially available CNIBP systems, including ClearSight, CNAP, Finapres NOVA, and the Cardiowatch PTT-based wearable. Literature review revealed that volume clamp–based systems demonstrate the strongest accuracy across perioperative and acute care settings, with ClearSight having the broadest validation, particularly for mean arterial pressure tracking. However, all devices exhibit diminished accuracy in extreme physiological states, including severe shock, obesity, and peripheral arterial disease. This guide summarizes device mechanisms, validated use cases, and limitations to support informed clinician adoption. Continued research is needed to expand validation across diverse clinical scenarios and develop CNIBP technologies capable of reliable performance at physiological extremes.