People who inject drugs (PWID) face substantial barriers to optimal treatment of serious infections, including high rates of self-directed discharge, fragmented follow-up, and limited eligibility for outpatient parenteral antimicrobial therapy (OPAT). A needs assessment at Dartmouth Health identified significant gaps in addiction treatment engagement, social support, and access to safe home environments. A multidisciplinary intervention was implemented incorporating Behavioral Intervention Team consultation, structured team meetings, harm-reduction counseling, and coordinated care navigation. Preliminary post-intervention data showed improved addiction treatment engagement (99%), increased discharge on home IV therapy (19% vs. 7%), and reduced need for prolonged inpatient IV therapy. Chart review indicated a 77% clinical cure rate at end of therapy, with manageable rates of adverse events and PICC complications. Continued evaluation will assess financial implications and feasibility in rural settings.