The rise of fentanyl contamination in non-opioid recreational drugs has led to dramatic increases in unintentional overdose deaths among adolescents and young adults. This cross-sectional online survey aims to characterize fentanyl risk awareness, harm-reduction behaviors, and barriers to tool utilization among individuals aged 18–25 who use non-opioid substances. Participants are recruited through social media, community outreach, and student organizations. The survey assesses substance-use patterns, perceived contamination risk, access to fentanyl test strips and naloxone, and preferred educational approaches. Early national data indicate that although overdose mortality has recently declined, awareness and engagement with harm-reduction tools remain low among young adults, who are disproportionately exposed through stimulant-containing party drugs. Findings from this study will support development of tailored, stigma-sensitive harm-reduction strategies designed to improve safety among young recreational users.